ABSTRACT
Background: Pyrethroid pesticide poisoning cases in developed and developing countries have a high incidence every year. One of the active substances in pyrethroid widely used is cypermethrin.In the 2006-2016 period, 30.789 cases of pesticide poisoningcaused by cypermethrinwere reported in Jiangsu Province, China. Among these cases, 12.867 involved men and 17.922 involved women. Overall, 1.705 cases ended in death. The effectsof cypermethrin intoxication on the kidneys, especially in humans, are little to be studied. This study aims to determine the difference in the histopathological image of the Wistarrat’s kidney.Method: The experimental research of the post-test only control group designinvolved 24 male Wistar rats divided into 4 groups randomly, the control (not given cypermethrin), treatments of 125 mg/kgBW, 250 mg/kgBW, and 500 mg/kgBW. Cypermethrin are given orally for 14 days. After the rats wereterminated, the kidney wereprocessedto be paraffin-embedded tissues and stained with HE. Tubular injuries were examined using 400x magnification of light microscope and focused on closure of tubular lumen as well as proteinaceous cast inside the lumens. Results:The results of this study showed that the means of histopathological damage to the kidneys increased from control group to 500 mg/kgBWtreatment group. Statistical analysis with One way ANOVAshowed significant differences (p<0.001), continued with Post hoc games Howelltest, there was a significant differences between control group with 250 mg/kgBWtreatment group and 500 mg/kgBWtreatment group, and between 125 mg/kgBWtreatment group with 250mg/kgBWtreatment group and 500 mg/kgBWtreatment group. There was no significant difference between the control group with 125 mg/kgBWgroup and 250 mg/kgBWtreatment group with 500 mg/kgBWtreatment group.Conclusion: There is a significant difference in renal histopathological image due to exposure to pyrethroid (cypermethrin) in gradual doses. The image of kidney damages can result in tubules injury which include: albuminous degeneration with narrowing of the tubular lumen and hyaline cast. The means of tubular injury rate will increase with increasing dose of pyrethroid.Keywords:cypermethrin; kidney damage; pyrethroid